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简单介绍:
TAS2R38, Antibody
详情介绍:
Product Name

TAS2R38, Antibody

Full Product Name

TAS2R38 Antibody

Product Gene Name

anti-TAS2R38 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
AF494231 Genomic DNA
3D Structure
ModBase 3D Structure for P59533
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-TAS2R38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-TAS2R38 antibody
Western Blot (WB), Immunohistochemistry (IHC)
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NCBI/Uniprot data below describe general gene information for TAS2R38. It may not necessarily be applicable to this product.
NCBI GI #
261490645
NCBI GeneID
5726
NCBI Accession #
NP_789787.4 [Other Products]
NCBI GenBank Nucleotide #
NM_176817.4 [Other Products]
UniProt Primary Accession #
P59533 [Other Products]
UniProt Secondary Accession #
P59552; Q2M3E8; Q645W3; Q86UK3; A4D1U6[Other Products]
UniProt Related Accession #
P59533[Other Products]
Molecular Weight
37,892 Da
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NCBI Official Full Name
taste receptor type 2 member 38
NCBI Official Synonym Full Names
taste 2 receptor member 38
NCBI Official Symbol
TAS2R38  [Similar Products]
NCBI Official Synonym Symbols
PTC; T2R38; T2R61
  [Similar Products]
NCBI Protein Information
taste receptor type 2 member 38
UniProt Protein Name
Taste receptor type 2 member 38
UniProt Synonym Protein Names
PTC bitter taste receptor; Taste receptor type 2 member 61; T2R61
Protein Family
Taste receptor
UniProt Gene Name
TAS2R38  [Similar Products]
UniProt Synonym Gene Names
PTC; T2R38; T2R61  [Similar Products]
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NCBI Summary for TAS2R38
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
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UniProt Comments for TAS2R38
TAS2R38: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family.

Protein type: GPCR, T2R family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: integral to membrane; plasma membrane

Molecular Function: bitter taste receptor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste

Disease: Thiourea Tasting
Research Articles on TAS2R38
1. Our investigation indicates that T2R38 genotype correlates both with SNOT-22 scores and rhinologic-specific quality of life in DeltaF508 homozygous cystic fibrosis patients
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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