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  • 产品名称:TAS2R38, Polyclonal Antibody

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简单介绍:
TAS2R38, Polyclonal Antibody
详情介绍:
Product Name

TAS2R38, Polyclonal Antibody

Popular Item
Full Product Name

TAS2R38 Antibody

Product Synonym Names
PTC; PTC bitter taste receptor; T2R38; T2R38_HUMAN; T2R61; TAS2R38; Taste receptor type 2 member 38; Taste receptor type 2 member 61; taste receptor, type 2, member 38
Product Gene Name

anti-TAS2R38 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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3D Structure
ModBase 3D Structure for P59533
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
TAS2R38 antibody detects endogenous levels of total TAS2R38
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human TAS2R38
Subcellular Location
Membrane.
Tissue Specificity
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).
Predicted Cross Reactivity
Pig, Sheep
Similarity
Pig (89%), Sheep (89%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-TAS2R38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-TAS2R38 antibody
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Similarity: Belongs to the G-protein coupled receptor T2R family.
Applications Tested/Suitable for anti-TAS2R38 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-TAS2R38 antibody
WB: 1:1000-3000
IHC: 1:200

Western Blot (WB) of anti-TAS2R38 antibody
Western blot analysis of TAS2R38 using COLO205 whole cell lysates
anti-TAS2R38 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TAS2R38 antibody
MBS9603125 at 1/100 staining Human Head and neck cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-TAS2R38 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TAS2R38. It may not necessarily be applicable to this product.
NCBI GI #
261490645
NCBI GeneID
5726
NCBI Accession #
NP_789787.4 [Other Products]
NCBI GenBank Nucleotide #
NM_176817.4 [Other Products]
UniProt Primary Accession #
P59533 [Other Products]
UniProt Secondary Accession #
P59552; Q2M3E8; Q645W3; Q86UK3; A4D1U6[Other Products]
UniProt Related Accession #
P59533[Other Products]
Molecular Weight
Observed: 38 kDa
Predicted: 38 kDa
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NCBI Official Full Name
taste receptor type 2 member 38
NCBI Official Synonym Full Names
taste 2 receptor member 38
NCBI Official Symbol
TAS2R38  [Similar Products]
NCBI Official Synonym Symbols
PTC; T2R38; T2R61; THIOT
  [Similar Products]
NCBI Protein Information
taste receptor type 2 member 38
UniProt Protein Name
Taste receptor type 2 member 38
UniProt Synonym Protein Names
PTC bitter taste receptor; Taste receptor type 2 member 61; T2R61
Protein Family
Taste receptor
UniProt Gene Name
TAS2R38  [Similar Products]
UniProt Synonym Gene Names
PTC; T2R38; T2R61  [Similar Products]
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NCBI Summary for TAS2R38
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
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UniProt Comments for TAS2R38
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 ().
Research Articles on TAS2R38
1. genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS]
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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