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简单介绍:
NRL, ELISA Kit
详情介绍:
Product Name

NRL, ELISA Kit

Full Product Name

NRL TFact DNA-Binding ELISA Kit

Product Synonym Names
Neural retina-specific leucine zipper protein; NRL; D14S46E
Product Gene Name

NRL elisa kit

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Request for Current Manual Insert
Request Current Manual
OMIM
M95925 mRNA
3D Structure
ModBase 3D Structure for P54845
Species Reactivity
Human, Mouse
Specificity
The TFact NRL DNA-Binding ELISA detects endogenous levels of NRL.
Form/Format
12 x 8-Well Microstrips
Samples
Cell lysate
Assay Type
DNA-Binding ELISA
Sensitivity
10-30 ug of total protein/well
Detection Method
Colorimetric 450 nm
Subtype
None
Preparation and Storage
Store at 4 degree C for 6 months.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of NRL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for NRL purchase
MBS9502318 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NRL, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NRL. The ELISA analytical biochemical technique of the MBS9502318 kit is based on NRL antibody-NRL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Testing Data of NRL elisa kit
The TFact NRL DNA-Binding ELISA detects active NRL in S-K-NAS and HEK293 Nuclear Extract. The S-K-NAS and HEK293 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract.
NRL elisa kit Testing Data image
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NCBI/Uniprot data below describe general gene information for NRL. It may not necessarily be applicable to this product.
NCBI GI #
5453802
NCBI GeneID
4901
NCBI Accession #
NP_006168.1 [Other Products]
NCBI GenBank Nucleotide #
NM_006177.4 [Other Products]
UniProt Primary Accession #
P54845 [Other Products]
UniProt Secondary Accession #
Q53XD0; A8MX14[Other Products]
UniProt Related Accession #
P54845[Other Products]
Molecular Weight
11,276 Da
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NCBI Official Full Name
neural retina-specific leucine zipper protein isoform 1
NCBI Official Synonym Full Names
neural retina leucine zipper
NCBI Official Symbol
NRL  [Similar Products]
NCBI Official Synonym Symbols
RP27; D14S46E; NRL-MAF
  [Similar Products]
NCBI Protein Information
neural retina-specific leucine zipper protein
UniProt Protein Name
Neural retina-specific leucine zipper protein
Protein Family
Neural retina-specific leucine zipper protein
UniProt Gene Name
NRL  [Similar Products]
UniProt Synonym Gene Names
D14S46E; NRL  [Similar Products]
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NCBI Summary for NRL
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
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UniProt Comments for NRL
NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: DNA binding; leucine zipper domain binding; protein binding

Biological Process: positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression; response to stimulus; retinal rod cell development; transcription from RNA polymerase II promoter; visual perception

Disease: Retinitis Pigmentosa 27
Research Articles on NRL
1. investigated the prevalence of the NRL mutation among Bukhara Jews with oculopharyngeal muscular dystrophy (OPMD)
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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