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  • 产品名称:Vang-like protein 2, ELISA Kit

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简单介绍:
Vang-like protein 2, ELISA Kit
详情介绍:
Product Name

Vang-like protein 2 (VANGL2), ELISA Kit

Full Product Name

Human Vang-like protein 2 ELISA Kit

Product Gene Name

VANGL2 elisa kit

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Request for Current Manual Insert
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OMIM
AB033041 mRNA
3D Structure
ModBase 3D Structure for Q9ULK5
Species Reactivity
Human
Assay Type
Sandwich
Detection Range
0.312-20 ng/mL
Sensitivity
0.194 ng/mL
Intra-Assay CV
<=5.5%< div="">
Inter-Assay CV
<=6.8%< div="">
Recovery
98%
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of VANGL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for VANGL2 purchase
MBS2888250 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Vang-like protein 2 (VANGL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VANGL2. The ELISA analytical biochemical technique of the MBS2888250 kit is based on VANGL2 antibody-VANGL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VANGL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VANGL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for VANGL2. It may not necessarily be applicable to this product.
NCBI GI #
62955805
NCBI GeneID
57216
NCBI Accession #
NP_065068.1 [Other Products]
NCBI GenBank Nucleotide #
NM_020335.2 [Other Products]
UniProt Primary Accession #
Q9ULK5 [Other Products]
UniProt Secondary Accession #
Q5T212; D3DVE9[Other Products]
UniProt Related Accession #
Q9ULK5[Other Products]
Molecular Weight
59,714 Da
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NCBI Official Full Name
vang-like protein 2
NCBI Official Synonym Full Names
VANGL planar cell polarity protein 2
NCBI Official Symbol
VANGL2  [Similar Products]
NCBI Official Synonym Symbols
LPP1; LTAP; STB1; STBM; STBM1
  [Similar Products]
NCBI Protein Information
vang-like protein 2
UniProt Protein Name
Vang-like protein 2
UniProt Synonym Protein Names
Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family
Vang-like protein
UniProt Gene Name
VANGL2  [Similar Products]
UniProt Synonym Gene Names
KIAA1215; STB1  [Similar Products]
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NCBI Summary for VANGL2
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
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UniProt Comments for VANGL2
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; COPII-coated ER to Golgi transport vesicle; integral component of membrane; intercellular junction; lateral plasma membrane; plasma membrane; stress fiber

Molecular Function: protein binding

Biological Process: anterior/posterior pattern specification; apical protein localization; cochlea morphogenesis; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; dopaminergic neuron axon guidance; establishment of body hair orientation; establishment of planar polarity; establishment of planar polarity involved in neural tube closure; establishment or maintenance of epithelial cell apical/basal polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor stereocilium organization and biogenesis; membranous septum morphogenesis; muscular septum morphogenesis; neural tube closure; non-motile cilium assembly; planar cell polarity pathway involved in axis elongation; planar cell polarity pathway involved in axon guidance; planar cell polarity pathway involved in neural tube closure; positive regulation of JUN kinase activity; regulation of actin cytoskeleton organization; regulation of Wnt receptor signaling pathway; Rho protein signal transduction; serotonergic neuron axon guidance; somatic stem cell division; somatic stem cell maintenance; wound healing

Disease: Neural Tube Defects
Research Articles on VANGL2
1. VANGL2 interacts with Integrin alphaVbeta3 to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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