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  • 产品名称:activin A receptor, type IIB, ELISA Kit

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简单介绍:
activin A receptor, type IIB, ELISA Kit
详情介绍:
Product Name

activin A receptor, type IIB (ACVR2B), ELISA Kit

Full Product Name

Human Activin receptor type-2B, ACVR2B ELISA Kit

Product Synonym Names
Human Activin receptor type-2B (ACVR2B) ELISA kit; ACTRIIB; ActR-IIB; MGC116908; ; activin A receptor; type IIB
Product Gene Name

ACVR2B elisa kit

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sample Manual Insert
Download Sample PDF Manual View Sample PDF Manual
Request for Current Manual Insert
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OMIM
gene 613751
3D Structure
ModBase 3D Structure for Q13705
Species Reactivity
Human
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Samples
Serum, Plasma and Tissue Homogenate
Assay Type
Sandwich
Detection Range
0.5ng/ml-16ng/ml.
Sensitivity
0.1ng/ml.
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of ACVR2B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for ACVR2B purchase
MBS9321527 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the activin A receptor, type IIB (ACVR2B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACVR2B. The ELISA analytical biochemical technique of the MBS9321527 kit is based on ACVR2B antibody-ACVR2B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACVR2B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACVR2B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for
ACVR2B elisa kit
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ACVR2B (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.
NCBI/Uniprot data below describe general gene information for ACVR2B. It may not necessarily be applicable to this product.
NCBI GI #
116734708
NCBI GeneID
93
NCBI Accession #
NP_001097.2 [Other Products]
NCBI GenBank Nucleotide #
NM_001106.3 [Other Products]
UniProt Primary Accession #
Q13705 [Other Products]
UniProt Secondary Accession #
Q4VAV0[Other Products]
UniProt Related Accession #
Q13705[Other Products]
Molecular Weight
– Da
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NCBI Official Full Name
activin receptor type-2B
NCBI Official Synonym Full Names
activin A receptor, type IIB
NCBI Official Symbol
ACVR2B  [Similar Products]
NCBI Official Synonym Symbols
HTX4; ACTRIIB; ActR-IIB
  [Similar Products]
NCBI Protein Information
activin receptor type-2B
UniProt Protein Name
Activin receptor type-2B
UniProt Synonym Protein Names
Activin receptor type IIB; ACTR-IIB
Protein Family
Activin receptor
UniProt Gene Name
ACVR2B  [Similar Products]
UniProt Synonym Gene Names
ACTR-IIB  [Similar Products]
UniProt Entry Name
AVR2B_HUMAN
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NCBI Summary for ACVR2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
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UniProt Comments for ACVR2B
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; growth factor binding; metal ion binding; activin binding; protein serine/threonine/tyrosine kinase activity; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; lymphangiogenesis; pancreas development; embryonic foregut morphogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ growth; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development

Disease: Heterotaxy, Visceral, 4, Autosomal
Research Articles on ACVR2B
1. Activin type IIB receptors are clearly demonstrable throughout the ***** human hypothalamus and basal forebrain.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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