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  • 产品名称:17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3), Polyclonal Antibody

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简单介绍:
17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3), Polyclonal Antibody
详情介绍:
Product Name

17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3), Polyclonal Antibody

Full Product Name

Cy3-Linked Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3)

Product Synonym Names
SDR12C2; EDH17B3; Short Chain Dehydrogenase/Reductase Family 12C, Member 2; Testosterone 17-Beta-Dehydrogenase 3; Testicular 17-beta-hydroxysteroid dehydrogenase
Product Gene Name

anti-HSD17b3 antibody

[Similar Products]
Matching Pairs
Unconjugated Antibody: 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (MBS2033852)
Cy3 Conjugated Antibody: 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) (MBS2076030)
Matching Pairs
Cy3 Conjugated Antibody: 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) (MBS2076030)
Immunogen: 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (MBS2034334)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Concentration
200ug/ml (lot specific)
Immunogen
HSD17b3 (Met1~Arg310)
Conjugation
Cy3
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2033852
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-HSD17b3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-HSD17b3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
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NCBI/Uniprot data below describe general gene information for HSD17b3. It may not necessarily be applicable to this product.
NCBI GI #
1513310
NCBI GeneID
15487
NCBI Accession #
AAB06793.1 [Other Products]
UniProt Secondary Accession #
G3UWF9[Other Products]
UniProt Related Accession #
P70385[Other Products]
Molecular Weight
34,330 Da
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NCBI Official Full Name
17-beta-hydroxysteroid dehydrogenase type 3
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 3
NCBI Official Symbol
Hsd17b3  [Similar Products]
NCBI Protein Information
testosterone 17-beta-dehydrogenase 3
UniProt Protein Name
Testosterone 17-beta-dehydrogenase 3
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase
Protein Family
Testosterone 17-beta-dehydrogenase
UniProt Gene Name
Hsd17b3  [Similar Products]
UniProt Synonym Gene Names
Edh17b3; 17-beta-HSD 3  [Similar Products]
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UniProt Comments for HSD17b3
HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: EC 1.1.1.64; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 13|13 B3

Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle

Molecular Function: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; estradiol 17-beta-dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: steroid biosynthetic process
Research Articles on HSD17b3
1. Enzyme activities of 3-betaHSDH increase as the sound pressure levels increase in adrenal cortex zona fasciculate polygonal cells.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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