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  • 产品名称:HSD17B3, Polyclonal Antibody

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简单介绍:
HSD17B3, Polyclonal Antibody
详情介绍:
Product Name

HSD17B3, Polyclonal Antibody

Full Product Name

HSD17B3 Antibody (Center)

Product Synonym Names
Testosterone 17-beta-dehydrogenase 3; 17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase; HSD17B3; EDH17B3
Product Gene Name

anti-HSD17B3 antibody

[Similar Products]
Antibody/Peptide Pairs
HSD17B3 peptide (MBS9228249) is used for blocking the activity of HSD17B3 antibody (MBS9212678)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Immunogen Sequence Positions
89-118
OMIM
264300
3D Structure
ModBase 3D Structure for P37058
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This HSD17B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the Central region of human HSD17B3.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-HSD17B3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-HSD17B3 antibody
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Product Categories/Family for anti-HSD17B3 antibody
Cancer; Cell Biology; Metabolism; Signal Transduction
Applications Tested/Suitable for anti-HSD17B3 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-HSD17B3 antibody
WB~~1:1000

Western Blot (WB) of anti-HSD17B3 antibody
Western blot analysis of HSD17B3 Antibody (Center) in K562 cell line lysates (35ug/lane). HSD17B3 (arrow) was detected using the purified Pab.
anti-HSD17B3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HSD17B3 antibody
Formalin-fixed and paraffin-embedded human testis tissue reacted with HSD17B3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-HSD17B3 antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-HSD17B3 antibody
HSD17B3 Antibody (Center) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-HSD17B3 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for HSD17B3. It may not necessarily be applicable to this product.
NCBI GI #
4557649
NCBI GeneID
3293
NCBI Accession #
NP_000188.1 [Other Products]
NCBI GenBank Nucleotide #
NM_000197.1 [Other Products]
UniProt Primary Accession #
P37058 [Other Products]
UniProt Secondary Accession #
Q5U0Q6[Other Products]
UniProt Related Accession #
P37058[Other Products]
Molecular Weight
34516
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NCBI Official Full Name
testosterone 17-beta-dehydrogenase 3
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 3
NCBI Official Symbol
HSD17B3  [Similar Products]
NCBI Official Synonym Symbols
EDH17B3; SDR12C2
  [Similar Products]
NCBI Protein Information
testosterone 17-beta-dehydrogenase 3
UniProt Protein Name
Testosterone 17-beta-dehydrogenase 3
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase
Protein Family
Testosterone 17-beta-dehydrogenase
UniProt Gene Name
HSD17B3  [Similar Products]
UniProt Synonym Gene Names
EDH17B3; SDR12C2; 17-beta-HSD 3  [Similar Products]
UniProt Entry Name
DHB3_HUMAN
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NCBI Summary for HSD17B3
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
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UniProt Comments for HSD17B3
HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: Oxidoreductase; EC 1.1.1.64; Lipid Metabolism - androgen and estrogen

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: steroid metabolic process; male genitalia development; androgen biosynthetic process

Disease: 17-beta Hydroxysteroid Dehydrogenase Iii Deficiency
Product References and Citations for anti-HSD17B3 antibody
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) :
Sata, F., et al. J Sex Med (2010) In press :
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
Beuten, J., et al. Cancer Epidemiol. Biomarkers Prev. 18(6):1869-1880(2009)
Andersson, S., et al. J. Clin. Endocrinol. Metab. 81(1):130-136(1996)

Research Articles on HSD17B3
1. These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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