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  • 产品名称:HSD17B3, Blocking Peptide

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简单介绍:
HSD17B3, Blocking Peptide
详情介绍:
Product Name

HSD17B3, Blocking Peptide

Full Product Name

HSD17B3 Immunizing Peptide

Product Synonym Names
HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; EDH17B3; SDR12C2; 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; short chain dehydrogenase/reductase family 12C, member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testo; HSD17B3 (aa141-155)
Product Gene Name

HSD17B3 blocking peptide

[Similar Products]
Product Synonym Gene Name
HSD17B3[Similar Products]
Antibody/Peptide Pairs
HSD17B3 peptide (MBS428733) is used for blocking the activity of HSD17B3 antibody (MBS423643)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence
C-SHFLNAPD EIQSLIH
OMIM
264300
Species Reactivity
Human
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of HSD17B3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HSD17B3. It may not necessarily be applicable to this product.
NCBI GI #
4557649
NCBI GeneID
3293
NCBI Accession #
NP_000188.1 [Other Products]
NCBI GenBank Nucleotide #
NM_000197.1 [Other Products]
UniProt Secondary Accession #
Q5U0Q6[Other Products]
UniProt Related Accession #
P37058[Other Products]
Molecular Weight
29,109 Da
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NCBI Official Full Name
testosterone 17-beta-dehydrogenase 3
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 3
NCBI Official Symbol
HSD17B3  [Similar Products]
NCBI Official Synonym Symbols
EDH17B3; SDR12C2
  [Similar Products]
NCBI Protein Information
testosterone 17-beta-dehydrogenase 3
UniProt Protein Name
Testosterone 17-beta-dehydrogenase 3
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase
Protein Family
Testosterone 17-beta-dehydrogenase
UniProt Gene Name
HSD17B3  [Similar Products]
UniProt Synonym Gene Names
EDH17B3; SDR12C2; 17-beta-HSD 3  [Similar Products]
UniProt Entry Name
DHB3_HUMAN
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NCBI Summary for HSD17B3
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
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UniProt Comments for HSD17B3
HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: Oxidoreductase; Lipid Metabolism - androgen and estrogen; EC 1.1.1.64

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: androgen biosynthetic process; male genitalia development

Disease: 17-beta Hydroxysteroid Dehydrogenase Iii Deficiency
Research Articles on HSD17B3
1. Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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