产品详情
  • 产品名称:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2), Recomb

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简单介绍:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2), Recombinant Protein
详情介绍:
Product Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2), Recombinant Protein

Full Product Name

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2) , partial

Product Gene Name

PLCH2 recombinant protein

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
612836
3D Structure
ModBase 3D Structure for O75038
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PLCH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PLCH2. It may not necessarily be applicable to this product.
NCBI GI #
732170479
NCBI GeneID
9651
NCBI Accession #
NP_001289941.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001303012.1 [Other Products]
UniProt Primary Accession #
O75038 [Other Products]
UniProt Secondary Accession #
Q3LUA8; Q86XJ2; Q86XU1; Q86YU7; Q8TEH5; Q8WUS6; A2VCM3; B9DI80[Other Products]
UniProt Related Accession #
O75038[Other Products]
Molecular Weight
52,942 Da
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NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 2
NCBI Official Synonym Full Names
phospholipase C eta 2
NCBI Official Symbol
PLCH2  [Similar Products]
NCBI Official Synonym Symbols
PLCL4; PLC-L4; PLCeta2; PLC-eta2
  [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; PLC-L4; Phospholipase C-like protein 4; Phospholipase C-eta-2; PLC-eta2
Protein Family
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name
PLCH2  [Similar Products]
UniProt Synonym Gene Names
KIAA0450; PLCL4; PLC-L4; Phospholipase C-like protein 4; PLC-eta2  [Similar Products]
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NCBI Summary for PLCH2
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
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UniProt Comments for PLCH2
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain ().
Research Articles on PLCH2
1. PLCH2 might be a putative candidate gene for the neurodevelopmental delay observed in patients bearing 1p36.3 deletions.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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