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  • 产品名称:Ferritin, Spleen, Protein

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简单介绍:
Ferritin, Spleen, Protein
详情介绍:
Product Name

Ferritin, Spleen (FTL), Protein

Full Product Name

Ferritin, Spleen, Human

Product Gene Name

FTL protein

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 10; NC_009153.2 (18929521..18930451). Location: chromosome: 10
3D Structure
ModBase 3D Structure for P02791
Host
Ferritin, from human spleen.
Purity/Purification
Purified
96% (SDS-PAGE)
Form/Format
Supplied as a liquid in sodium chloride, pH 7.5. No preservative added.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of FTL protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
FTL protein
Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450kD, consisting of 24 subunits of two types, H (heavy; 21kD) and L (light; 19kD), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
Product Categories/Family for FTL protein
Molecular Biology; MB-Ferritin
Applications Tested/Suitable for FTL protein
ELISA (EL/EIA)
Application Notes for FTL protein
Suitable for use in ELISA. Other applications not tested
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NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
NCBI GI #
167621435
NCBI GeneID
100051593
NCBI Accession #
NP_001108012.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001114540.1 [Other Products]
UniProt Primary Accession #
P02791 [Other Products]
UniProt Secondary Accession #
Q53VB4[Other Products]
UniProt Related Accession #
P02791[Other Products]
Molecular Weight
19,978 Da[Similar Products]
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NCBI Official Full Name
ferritin light chain
NCBI Official Symbol
FTL  [Similar Products]
NCBI Official Synonym Symbols
FT
  [Similar Products]
NCBI Protein Information
ferritin light chain; ferritin L subunit
UniProt Protein Name
Ferritin light chain
Protein Family
Ferritin
UniProt Gene Name
FTL  [Similar Products]
UniProt Synonym Gene Names
Ferritin L subunit  [Similar Products]
UniProt Entry Name
FRIL_HORSE
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UniProt Comments for FTL
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney

By similarity.

Subunit structure: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Miscellaneous: In horse spleen the light chain is the major chain.

Sequence similarities: Belongs to the ferritin family.Contains 1 ferritin-like diiron domain.
Research Articles on FTL
1. Transmission electron microscopy shows a clear selectivity of alkylated ferritin adsorption onto the PCL phase while wild ferritin predominantly adsorbs onto the PDTD phase.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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