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  • 产品名称:ATRX, Blocking Peptide

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简单介绍:
ATRX, Blocking Peptide
详情介绍:
Product Name

ATRX, Blocking Peptide

Full Product Name

ATRX Peptide - C-terminal region

Product Gene Name

ATRX blocking peptide

[Similar Products]
Antibody/Peptide Pairs
ATRX peptide (MBS3233720) is used for blocking the activity of ATRX antibody (MBS3208757)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence
Synthetic peptide located within the following region: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE
OMIM
300032
3D Structure
ModBase 3D Structure for P46100
Species Reactivity
Human
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of ATRX blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
ATRX blocking peptide
This is a synthetic peptide designed for use in combination with anti-ATRX Antibody, made

Target Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Product Categories/Family for ATRX blocking peptide
Peptide
Applications Tested/Suitable for ATRX blocking peptide
Western Blot (WB)
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NCBI/Uniprot data below describe general gene information for ATRX. It may not necessarily be applicable to this product.
NCBI GI #
20336209
NCBI GeneID
546
NCBI Accession #
NP_000480.2 [Other Products]
NCBI GenBank Nucleotide #
NM_000489.3 [Other Products]
UniProt Primary Accession #
P46100 [Other Products]
UniProt Related Accession #
P46100[Other Products]
Molecular Weight
148kDa
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NCBI Official Full Name
transcriptional regulator ATRX isoform 1
NCBI Official Synonym Full Names
ATRX chromatin remodeler
NCBI Official Symbol
ATRX  [Similar Products]
NCBI Official Synonym Symbols
JMS; XH2; XNP; MRX52; RAD54; RAD54L; ZNF-HX
  [Similar Products]
NCBI Protein Information
transcriptional regulator ATRX
UniProt Protein Name
Transcriptional regulator ATRX
UniProt Synonym Protein Names
ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX
Protein Family
Transcriptional regulator
UniProt Gene Name
ATRX  [Similar Products]
UniProt Synonym Gene Names
RAD54L; XH2; XNP  [Similar Products]
UniProt Entry Name
ATRX_HUMAN
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NCBI Summary for ATRX
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
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UniProt Comments for ATRX
ATRX: a global transcriptional regulator. Belongs to the SNF2 family of proteins, many of which modify gene expression via chromatin remodeling activity. Involved in the developmental silencing of imprinted genes in the brain. Contains one PxVxL motif, which is required for interaction with chromoshadow domains. This motif requires additional residues at -7, -6, +4 and +5 relative to the central V which contact the chromoshadow domain. Constitutive mutations in ATRX are associated with brain, facial, and genital abnormalities, and alpha thalassemia. Acquired mutations in ATRX have been observed in preleukemic conditions. Six alternatively spliced human isoforms have been described.

Protein type: DNA repair, damage; Ubiquitin conjugating system; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: nucleoplasm; PML body; nuclear heterochromatin; nucleus

Molecular Function: protein binding; DNA helicase activity; DNA binding; histone binding; zinc ion binding; chromatin binding; helicase activity; DNA translocase activity; methylated histone residue binding; ATP binding

Biological Process: transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; positive regulation of telomere maintenance; DNA repair; Sertoli cell development; DNA duplex unwinding; replication fork processing; DNA recombination; chromatin remodeling; nucleosome assembly; DNA replication-independent nucleosome assembly; regulation of transcription, DNA-dependent; forebrain development; DNA methylation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter

Disease: Alpha-thalassemia/mental Retardation Syndrome, X-linked; Mental Retardation-hypotonic Facies Syndrome, X-linked, 1; Alpha-thalassemia Myelodysplasia Syndrome
Research Articles on ATRX
1. ATRX has a broad spectrum of functions in normal cells and its disruption has been associated with several alterations in glioma and other cancers
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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