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  • 产品名称:Connexin 30 / GJB6, Blocking Peptide

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简单介绍:
Connexin 30 / GJB6, Blocking Peptide
详情介绍:
Product Name

Connexin 30 / GJB6, Blocking Peptide

Full Product Name

Connexin 30 / GJB6 Immunizing Peptide

Product Synonym Names
GJB6; gap junction protein, beta 6, 30kDa; CX30; DFNA3; ED2; EDH; HED; OTTHUMP00000018096; OTTHUMP00000176870; OTTHUMP00000176871; OTTHUMP00000176872; connexin 30; ectodermal dysplasia 2, hidrotic (Clouston syndrome); gap junction protein, beta 6; gap jun; Connexin 30; Connexin 30 / GJB6
Product Gene Name

GJB6 blocking peptide

[Similar Products]
Antibody/Peptide Pairs
Connexin 30 / GJB6 peptide (MBS426617) is used for blocking the activity of Connexin 30/GJB6 antibody (MBS421867)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence
C-RSKRAQTQ KNHPNH
OMIM
129500
Species Reactivity
Human, Mouse, Rat, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of GJB6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GJB6. It may not necessarily be applicable to this product.
NCBI GI #
40254837
NCBI GeneID
10804
NCBI Accession #
NP_006774.2 [Other Products]
NCBI GenBank Nucleotide #
NM_006783.4 [Other Products]
UniProt Secondary Accession #
Q5Q1H9; Q5Q1I0; Q5Q1I1; Q5T5U0; Q8IUP0; B3KQN2[Other Products]
UniProt Related Accession #
O95452[Other Products]
Molecular Weight
30,387 Da
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NCBI Official Full Name
gap junction beta-6 protein
NCBI Official Synonym Full Names
gap junction protein beta 6
NCBI Official Symbol
GJB6  [Similar Products]
NCBI Official Synonym Symbols
ED2; EDH; HED; CX30; HED2; DFNA3; ECTD2; DFNA3B; DFNB1B
  [Similar Products]
NCBI Protein Information
gap junction beta-6 protein
UniProt Protein Name
Gap junction beta-6 protein
UniProt Synonym Protein Names
Connexin-30; Cx30
Protein Family
Gap junction beta-6 protein
UniProt Gene Name
GJB6  [Similar Products]
UniProt Synonym Gene Names
Cx30  [Similar Products]
UniProt Entry Name
CXB6_HUMAN
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NCBI Summary for GJB6
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
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UniProt Comments for GJB6
GJB6: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. A connexon is composed of a hexamer of connexins. Interacts with CNST

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: apical plasma membrane; cell junction; connexon complex; cytosol; integral to membrane

Biological Process: aging; apoptosis; cell communication; ear morphogenesis; inner ear development; negative regulation of cell proliferation; response to electrical stimulus; response to lipopolysaccharide; sensory perception of sound

Disease: Clouston Syndrome; Deafness, Autosomal Dominant 3b; Deafness, Autosomal Recessive 1a; Deafness, Autosomal Recessive 1b; Deafness, X-linked 2
Research Articles on GJB6
1. Periostin is a robust marker of glioma malignancy and potential tumor recurrence. Abrogation of glioma stem cell tumorigenicity after periostin inhibition provides support for exploring the therapeutic impact of targeting periostin.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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