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  • 产品名称:TRPC6, Blocking Peptide

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简单介绍:
TRPC6, Blocking Peptide
详情介绍:
Product Name

TRPC6, Blocking Peptide

Full Product Name

TRPC6 Immunizing Peptide

Product Synonym Names
TRPC6; transient receptor potential cation channel, subfamily C, member 6; HGNC: 12338; TRP6; transient receptor potential channel 6; FLJ11098; FLJ14863; FSGS2; TRP6
Product Gene Name

TRPC6 blocking peptide

[Similar Products]
Antibody/Peptide Pairs
TRPC6 peptide (MBS428146) is used for blocking the activity of TRPC6 antibody (MBS421378)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence
C-EKLSMEPN QEETN
OMIM
603652
Species Reactivity
Human, Dog, Pig, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TRPC6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TRPC6. It may not necessarily be applicable to this product.
NCBI GI #
5730102
NCBI GeneID
7225
NCBI Accession #
NP_004612.2 [Other Products]
NCBI GenBank Nucleotide #
NM_004621.5 [Other Products]
UniProt Secondary Accession #
Q52M59; Q9HCW3; Q9NQA8; Q9NQA9[Other Products]
UniProt Related Accession #
Q9Y210[Other Products]
Molecular Weight
100,106 Da
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NCBI Official Full Name
short transient receptor potential channel 6
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily C member 6
NCBI Official Symbol
TRPC6  [Similar Products]
NCBI Official Synonym Symbols
TRP6; FSGS2
  [Similar Products]
NCBI Protein Information
short transient receptor potential channel 6
UniProt Protein Name
Short transient receptor potential channel 6
UniProt Synonym Protein Names
Transient receptor protein 6; TRP-6
Protein Family
Short transient receptor potential channel
UniProt Gene Name
TRPC6  [Similar Products]
UniProt Synonym Gene Names
TRP6; TrpC6; TRP-6  [Similar Products]
UniProt Entry Name
TRPC6_HUMAN
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NCBI Summary for TRPC6
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
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UniProt Comments for TRPC6
TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 11q22.1

Cellular Component: cytoplasm; cytosol; integral to plasma membrane; membrane; plasma membrane

Molecular Function: actin binding; actinin binding; ATPase binding; calcium channel activity; clathrin binding; protein binding; store-operated calcium channel activity

Biological Process: aging; cation transport; cytosolic calcium ion homeostasis; elevation of cytosolic calcium ion concentration; manganese ion transport; negative regulation of dendrite morphogenesis; neuron differentiation; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; positive regulation of neuron differentiation; single fertilization

Disease: Focal Segmental Glomerulosclerosis 2
Research Articles on TRPC6
1. the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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